Next-Generation Cybersecurity

targeted radiopharmaceutical therapy

Next-Generation Cybersecurity: Technology Overview

For decades, cybersecurity relied on a relatively simple principle: protect the network perimeter, scan for known threats and control access through passwords and permissions. This approach worked well when data was stored in corporate data centres, employees worked mainly within office networks and attacks followed more familiar patterns.

Today, data and applications are spread across cloud environments, employees and devices connect from almost anywhere, and industrial systems, power grids and vehicles are increasingly connected. Meanwhile, attackers use automation and AI to develop sophisticated attacks, create convincing deepfakes and exploit weaknesses in hardware and supply chains. Advances in quantum computing could eventually undermine some of today’s encryption methods. These developments are driving demand for new approaches to cybersecurity, beyond simply improving existing tools.

We have identified five technology areas that illustrate this next generation of cybersecurity. Their patent landscapes show how quickly they are developing, where innovation is concentrated and which companies are building strong technological positions. The analysis covers specialist cybersecurity vendors and technology, semiconductor and platform companies, as well as companies from industries such as finance, telecommunications, energy and utilities. These industries are major users of cybersecurity technologies and also contribute to innovation through their own patent activity.

Patents offer an early indication of technological change, often years before new capabilities reach the market or become visible in company revenues. Tracking patent activity and technological strength can therefore help identify emerging areas of innovation and the companies developing capabilities in these fields.

Explore the five technologies below to learn how they work, where they are applied and why they matter.

Intelligent Threat Design

What it covers:

AI-driven threat detection and response, cloud-native and API security, zero-trust architectures, protection of industrial control systems, IoT devices and connected vehicles, and software supply-chain security.

Traditional security tools often rely on known attack patterns and predefined rules. AI-driven systems can analyse behaviour across users, devices, networks and cloud workloads to identify suspicious activity, including previously unseen threats. Zero-trust architectures move away from the assumption that everything inside a corporate network is trustworthy, requiring access requests to be verified continuously. These approaches are also increasingly important for industrial systems, where cyberattacks can have physical consequences, and for software supply chains, where a compromised component can expose thousands of organisations to risk.

Why it matters:

Attackers are increasingly automating their operations, while the number of connected systems to protect continues to grow. Security must become more adaptive and automated in response. Intelligent threat defense moves beyond static rules towards systems that can detect, investigate and respond to threats with less manual intervention.

AI & Deepfake Security

What it covers:

Protection of AI models against manipulation, data poisoning, jailbreaks and adversarial attacks; security of AI agents; detection of deepfakes and synthetic media; media forensics; and content provenance and watermarking for AI-generated material.

As artificial intelligence becomes embedded in business processes, AI systems themselves are increasingly becoming targets. Attackers can poison training data, manipulate model inputs or exploit weaknesses in language models and autonomous agents to trigger unintended actions. At the same time, generative AI makes it easier to create realistic fake images, videos and voices, which can be used for fraud, impersonation and disinformation. This field covers technologies that protect AI systems from attacks and help identify content that has been artificially generated or manipulated.

Why it matters:

Trust in AI systems and digital content is becoming increasingly important to the digital economy. AI & Deepfake Security is an emerging area of cybersecurity, with patent activity reflecting growing efforts to address risks that have gained prominence only in recent years.

Identity & Anti-Fraud

What it covers:

Passwordless and continuous authentication, decentralised digital identity and identity wallets, biometric liveness detection and anti-spoofing for face and voice, identity management for machines and workloads, and AI-based detection of payment fraud, account takeover and money laundering.

Stolen credentials and compromised identities are behind many successful cyberattacks. Next-generation identity technologies reduce reliance on passwords through cryptographic credentials and biometrics, verify users continuously based on behaviour, and give individuals greater control over their digital identities. As criminals increasingly use deepfakes and synthetic identities to bypass verification, liveness detection and AI-driven fraud analytics are becoming more important.

Why it matters:

As more transactions, services and interactions move online, reliably verifying who or what is on the other side becomes critical. This applies not only to people, but also to devices, software and AI agents, making identity security central to both cybersecurity and digital commerce.

Quantum & Hardware Security

What it covers:

Quantum key distribution, quantum random number generation, post-quantum cryptography and crypto-agility, as well as hardware-based security technologies such as physically unclonable functions, hardware roots of trust, secure boot and firmware attestation, and protection against side-channel and physical attacks.

Cryptographically relevant quantum computers could break many of the public-key cryptographic methods used to protect digital communications today. This creates a risk that data intercepted now could be decrypted in the future. Post-quantum cryptography develops algorithms designed to withstand such attacks, with NIST publishing its first post-quantum cryptography standards in 2024. Quantum key distribution offers a different approach, using quantum-mechanical properties to help secure key exchange.

Security also increasingly relies on protections built directly into hardware. These include chips with unique physical characteristics, trusted boot processes and countermeasures against attacks that extract secrets through power-consumption measurements or deliberate hardware faults.

Why it matters:

The transition to quantum-resistant cryptography will require extensive changes to digital infrastructure, from communication networks to connected devices. Hardware security provides an additional layer of protection, helping establish trust in the systems on which software and digital services depend.

Privacy & Confidential Computing

What it covers:

Homomorphic encryption, secure multi-party computation, zero-knowledge proofs, differential privacy and privacy-preserving machine learning, as well as confidential computing based on hardware-protected trusted execution environments.

Conventional encryption protects data while it is stored or transmitted, but data generally needs to be decrypted for processing, potentially exposing it to unauthorised access. Privacy-enhancing technologies address this gap in different ways. They enable computations on encrypted data, joint analysis across organisations without directly sharing sensitive information, or verification of specific facts without revealing the underlying data. Confidential computing uses hardware-protected environments to isolate data and AI models from other software running on the same system, including, in some configurations, access by cloud operators.

Why it matters:

Organisations want to use sensitive data for AI, research and business collaboration, but privacy requirements, regulation and commercial concerns often limit what they can share. Privacy-enhancing technologies make it possible to extract value from data while reducing exposure and retaining greater control over its use, creating opportunities in healthcare, finance and cross-border data collaboration.

Global trends: sharp rise in Next-Generation Therapeutics patents

Indexed global development of patents in Next-Generation Therapeutics compared to established Pharma and Biotech technologies

Active Patents in Next-Generation Therapeutics have more than tripled since 2015 

The number of active patent family publications in the seven defined Next-Generation Therapeutics increased from around 21,000 in 2015 to almost 65,000 at the end of September 2026. As a result, patent growth has been more dynamic than in established pharma and biotech technologies.

Global development of patents in the seven Next-Generation Therapeutics

RNA Therapeutics is the largest patent area within Next-Generation Therapeutics

The number of active patent family publications in RNA Therapeutics increased from around 10,700 in 2015 to more than 30,000 in 2026. Other large areas are Engineered Cell Therapies and Genetic Medicines, both with more than 17,000 active patent family publications in 2026. The remaining four areas have smaller patent bases but are growing rapidly. The highest growth rate can be observed in Targeted Protein Degradation, where the number of patent family publications increased from just 45 in 2015 to more than 2,400 in 2026, equivalent to an annual growth rate of almost 44%.

Top research countries and companies in Next-Generation Therapeutics

Next-Generation Therapeutics: Transformative Score

The Transformative Score is a proprietary EconSight metric that assesses a company’s recent innovation strength. It combines indicators of patent dynamics and patent strength within Next-Generation Therapeutics to provide a forward-looking ranking of innovative companies.

The chart covers more than 500 listed companies active in Next-Generation Therapeutics. The Y-axis combines patent quality indicators, including the share and level of World-Class Patents, average patent quality and its development over the past five years. The X-axis measures patent quantity, combining the level of patent activity with its growth over the same period. Bubble size reflects each company’s degree of specialisation in Next-Generation Therapeutics.

Together, the two axes distinguish between the strength of an existing innovation position and its recent momentum. The three highlighted companies illustrate these different profiles.

Roche is the clear leader in total active patents and World-Class Patents in Next-Generation Therapeutics in 2026. It is also the only company with a substantial position across all seven technology areas. Its strongest position is in bispecific and multispecific therapeutics, complemented by strong portfolios in RNA therapeutics and targeted conjugates. However, when patent dynamics and specialisation are taken into account, Roche ranks 42nd among listed companies. This reflects the maturity and breadth of its portfolio rather than a lack of technological strength.

Moderna has a different profile and ranks among the top five on the Transformative Score. Its portfolio is highly concentrated in RNA therapeutics, resulting in one of the highest specialisation scores in the universe. Its research spans both RNA engineering and delivery technologies, with applications extending beyond vaccines into areas such as personalised cancer vaccines.

Dyne Therapeutics, also among the top five, shows how a smaller company can achieve a strong position through focused innovation. Its research centres on targeted delivery of oligonucleotide therapies to muscle tissue, placing it at the intersection of RNA therapeutics and targeted conjugates.

Roche represents the strongest established position, while Moderna and Dyne illustrate faster-moving innovation profiles. The Transformative Score captures both dimensions, providing a broader view of technological positioning than company size or patent volume alone.